P-152: The Effect of Hops (Humulus lupulus L) Extracts on Hormone Levels and Sexual Cells in Adult Male Mice
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Abstract:
Background: Hops Plant (Humulus lupulus L.) plants is very beneficial has many industrial and medical applications. hops has protein, amino acids, lipids, fatty acids, sugars such as glucose and fructose, pectin, salts, wax and estrogenic compounds. So the aim of this study was to evaluate the effect of hops extracts on hormone levels and sex cells in adult mice. Materials and Methods: 40 adult male mice used in research are divided into four main groups, each consisting of five subgroups of 8 groups were divided into of control, experiment 1, 2 and 3. The experimental group received daily 50, 100 and 150 mg / kgBW Hops extract was given orally. At the end of 35 days, using the ether imbued cotton in a jar of anesthesia, after anesthetized, blood from the left ventricle was performed, and the testes removed, the tissue sections were prepared for evaluation of tissue changes. Samples stained with hematoxylin - eosin was performed. Levels of testosterone and progestin hormones estrogen and sex cells also were examined And Independent sample t test and ANOVA were used (p ≤0/05). Results: The results of this study indicate that extracts of hops increases testosterone and estrogen in the experimental group, While they do not show a significant effect on progesterone. It also increases the number of, spermatogonia cells, and spermatid in experimental group. Conclusion: This study showed that extracts of hops can affect on hormone levels and sexual cells in adult male mouse and this plant can be useful in treatment of infertility.
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Journal title
volume 8 issue 2.5
pages 163- 163
publication date 2014-07-01
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